Deborah Kaplan

Targeted agents with activity against the VEGF pathway are showing promising efficacy in the treatment of bone and soft tissue sarcomas (STS) and may offer new therapy options for patients with these rare tumor types.
Although investigators are working to determine which patients see the most benefit from VEGF inhibition, the data indicate that it has activity in patients across most sarcoma types.
STS is a highly vascular disease, and inhibiting angiogenesis by way of the VEGF signaling path...

If you have a rash that appeared suddenly or recurs intermittently, you may be unsure of its cause. Rashes are associated with everything from scabies to allergic reactions to lupus. A lupus rash, like all types of rashes, needs specialized treatment.
Before discussing lupus rashes, it’s helpful to know more about lupus. This chronic inflammatory disease sometimes affects only the skin, but it also can affect other organs and systems, including the joints, brain, heart, blood, and kidneys. An...

If you’re like 70% of college students, you’re going to graduate with student debt. And if you’re among the lucky 30% who don’t, well, you probably still want to watch your wallet while hitting the books, to start off post-college life in the best financial position.
Anyone can make a budget, not just finance and accounting majors. It doesn’t have to be as painful as wisdom teeth removal. And having a budget can actually give you confidence throughout the school year. You’ll know ...

You may know how you want your assets and personal belongings to be handled upon your death, but if you haven't officially made these desires known, you can't assume that your loved ones know your wishes — and will honor them. Without a will and testament, also called a legal will, those wishes aren't legally binding.
What Is a Will?
A will is a written document stating a person's final wishes for their money, their property and people in their care. Though that's the general concept, legal w...

Kelly DiMaggio was used to being the patient. She was the one born with half a heart. She was the one who went through three open-heart surgeries before turning 8. She was the one with irregular heartbeats, blood clots and constant fatigue as an adult. She was the one who pushed herself to lose 30 pounds through eating healthier and exercising more.
Her husband, Mike, was always the caregiver – until December 2017, when he had surgery on a finger. Now it was...

It's important for small business owners to understand the logistics of the employer open enrollment period and how it affects employees. Knowing what open enrollment is and when it occurs can help set you and your employees up for success. Here's the information you might need to know.
What Is Open Enrollment?
Open enrollment is the period when employees can sign up for a new health insurance plan or change their existing plan for the coming year. It's also the period when employees can alte...

According to the Centers for Disease Control and Prevention (CDC), heart disease is the leading killer of women in the United States, with one in four women dying of heart disease. The good news, reports the American Heart Association, is that 80 percent of strokes and heart disease events are preventable with lifestyle changes.
Why is the risk of heart disease in women higher than in men? The populations share many health concerns, but women have additional risk factors. It’s important to be...

A colonoscopy is one of the best ways to detect colon cancer early, but colonoscopy preparation can cause stress and anxiety. Knowing what to expect when getting ready for a colonoscopy can help to make the process easier.

First, it’s helpful to understand why a colonoscopy is recommended. Colorectal cancer is the third most common type of cancer diagnosed in the United States for women and men. Every year, 145,000 Americans are diagnosed with colon or rectal cancer, according to the American...

Presentations at the 60th American Society of Hematology (ASH) Annual Meeting & Exposition were dominated by advancements in the treatment of chronic lymphocytic leukemia (CLL). Searches for CLL among oral presentations and poster sessions yield 371 entries.1 High on the list of discussions was the efficacy of standard-of-care ibrutinib (Imbruvica) and novel immunotherapy combination regimens.
“This was a big year at ASH for targeted therapy,” said Jennifer A. Woyach, MD, associate professor ...

Opportunity cost isn’t generally taught at business school, but the concept is used every day in a variety of business functions, including operations management. It’s the idea of trading one thing for another, and hoping to get more benefit from the chosen action, Funda Sahin PhD, associate professor of supply chain management at University of Houston, told Supply Chain Dive.
One example is considering how to introduce a product to the market. Managers must decide whether to introduce it en ...

Everyone flies the coop eventually, but you want to help your children be positioned for success. Whether your child stayed home to work after high school, moved home after college, or returned home after living on their own, eventually you may wonder, "When are my children leaving home for good?" You may need to prepare yourself to have a conversation with them about moving out. Here are some tips to consider.
Preparing for the Conversation
Before bringing up the topic, think about why now i...

The IRS is probably the last organization to be heralded as a pioneer in robotic process automation (RPA). Yet the agency is set to launch its newly tested automation program to zip through approximately 4,300 yearly compliance checks for new vendors, decreasing the manual processing time from two to four hours down to just two minutes.
This couldn’t come at a better time. Since 2010, the agency lost almost 40% of its contracting specialists and 16% of its funding, while the workload has rise...